Textbook in PDF format

This book presents the evidence related to the use of injectable biologics to provide faster and better healing for musculoskeletal lesions and conditions. The authors discuss approaches, such as blood derivatives and cell concentrates, applied to lesions of muscles, ligaments, tendons, bones, meniscus and cartilage, as well as osteoarthritis. Chapters are written by some of the most influential opinion leaders in the field, with up-to-date review of the current literature, where the authors explore both the potential and the limitations of these minimally invasive and promising treatments. The first section is devoted to the formulations and rationale for the use of injectable orthobiologics, while the second section reviews current treatment methods applied to specific joints and pathologies – ranging from tendinopathies through non-unions to articular degenerative processes – as well as the results of these treatment approaches. The third section explores future perspectives, such as pluripotent stem cells, gene therapy, and the stimulation of intrinsic stromal cell niches. Appealing to a broad readership, this book will be of interest to both laboratory research scientists and clinicians, including orthopedists, sports physicians, physiatrists, and regenerative medicine experts.
Injectable Orthobiologics: Formulations and Rationale
The Stem and Progenitor Cell Paradigms and Engineering Principles Guiding the Clinical Use of Cells or Cell-Derived Products for Regenerative Medicine
Bone Marrow as a Source of Cells for Musculoskeletal Cellular Therapies
Adipose-Derived Stem/​Stromal Cells, Stromal Vascular Fraction, and Microfragmented Adipose Tissue
Injections of Synovial Mesenchymal Stromal Cells
Placenta, Umbilical Cord, and Umbilical Cord Blood-Derived Cultured Stromal Cells
Injectable Allogenic Mesenchymal Stromal Cells:​ Advantages, Disadvantages, and Challenges
Injection of Steroid Hormones
Intra-articular Hyaluronic Acid Injections
Cytokines, Chemokines, Alpha-2-Macroglobulin, Growth Factors
Platelet-Rich Plasma:​ Processing and Composition
Placental Tissue Extracts
Secretome, Extracellular Vesicles, Exosomes
Injectable Orthobiologics: Methods and Results Based on Anatomy and Pathology
Rotator Cuff Tendinopathy:​ Cell Therapy
Rotator Cuff Tendinopathy:​ Biologics
Orthobiologics for the Treatment of Tennis Elbow
Patellar Tendinopathy:​ Cell Therapy
Patellar Tendinopathy:​ Biologics
Orthobiologics for the Treatment of Achilles Tendinopathy
Orthobiologics for the Treatment of Plantar Fasciitis
Ligament Lesions:​ Cell Therapy
Ligament Lesions:​ Biologics
Meniscal Lesions:​ Cell Therapy
Meniscal Lesions:​ Biologics
Orthobiologics for the Treatment of Muscle Lesions
Cartilage Lesions and Osteoarthritis:​ Cell Therapy
Cartilage Lesions and Osteoarthritis of the Knee:​ Biologics
Cartilage Lesions and Osteoarthritis of the Hip and Ankle:​ Orthobiologics
Injectable Orthobiologics for the Treatment of Subchondral Insufficiency Fractures of the Knee (SIFK) and Related Pathogenic Processes
Injections:​ Orthobiologics and the Power of Placebo
Future Directions
Pluripotent Stem Cells:​ Embryonic/​Fetal Stem Cells and Induced Pluripotent Stem Cells
Gene Therapy
In Situ Targeting of Stem and Progenitor Cells in Native Tissues