Textbook in PDF format

This book addresses multiple aspects of biological clocks in prokaryotes.
The first part of the book deals with the circadian clock system in cyanobacteria, i.e. the pioneer of bacterial clocks. Starting with the history and background of cyanobacteria and circadian rhythms in microorganisms, the topics range from the molecular basis, structure and evolution of the circadian clock to modelling approaches, Kai systems in cyanobacteria and biotechnological applications.
In the second part, emergent timekeeping properties of bacteria in microbiomes and bacteria other than cyanobacteria are discussed.
Since the discovery of circadian rhythms in cyanobacteria in the late 1980s, the field has exploded with new information. The cyanobacterial model system for studying circadian rhythms (Synechococcus elongatus), has allowed a detailed genetic dissection of the bacterial clock due to state-of-the-art methods in molecular, structural, and evolutionary biology. Cutting-edge research spanning from cyanobacteria and circadian phenomena in other kinds of bacteria, to microbiomes has now given the field another major boost.
This book is aimed at junior and senior researchers alike. Students or researchers new to the field of biological clocks in prokaryotes will get a comprehensive overview, while more experienced researchers will get an update on the latest developments.
Dedications
Dedication to Dr. Carol Rae Andersson (May 5, 1965-January 24, 2009) She left us too soon!
Dedication to Dr. Yohko Kitayama (1976-2016)
To Takao Kondo on the Occasion of His Retirement
Acknowledgments
References
Preface
The Bacterial Perspective on Circadian Clocks
The Circadian Clock System in Cyanobacteria: Pioneer of Bacterial Clocks
Around the Circadian Clock: Review and Preview
A Retrospective: On Disproving the Transcription-Translation Feedback Loop Model in Cyanobacteria
Mechanistic Aspects of the Cyanobacterial Circadian Clock
Mechanism of the Cyanobacterial Circadian Clock Protein KaiC to Measure 24 Hours
Oscillation and Input Compensation in the Cyanobacterial Kai Proteins
Insights into the Evolution of Circadian Clocks Gleaned from Bacteria
Reasons for Seeking Information on the Molecular Structure and Dynamics of Circadian Clock Components in Cyanobacteria
Single-Molecule Methods Applied to Circadian Proteins with Special Emphasis on Atomic Force Microscopy
Diversity of Timing Systems in Cyanobacteria and Beyond
An In Vitro Approach to Elucidating Clock-Modulating Metabolites
Damped Oscillation in the Cyanobacterial Clock System
Roles of Phosphorylation of KaiC in the Cyanobacterial Circadian Clock
Reprogramming Metabolic Networks and Manipulating Circadian Clocks for Biotechnological Applications
Insights from Mathematical Modeling/Simulations of the In Vitro KaiABC Clock
Circadian Phenomena in Microbiomes/Populations and Bacteria Besides Cyanobacteria
Basic Biology of Rhythms and the Microbiome
Disease Implications of the Circadian Clocks and Microbiota Interface
Circadian Organization of the Gut Commensal Bacterium Klebsiella aerogenes
Daily Rhythmicity in Coastal Microbial Mats
Daily and Seasonal Rhythms of Marine Phages of Cyanobacteria