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Neuroscience for Clinicians is a comprehensive and clinically relevant survey of emerging concepts on the organization and function of the nervous system and neurologic disease mechanisms. By emphasizing how genetic, molecular, and cellular processes and their interactions control the function of the nervous system, the work will help clinicians understand emerging concepts about the mechanisms of neurologic disorders including neurodegeneration, channelopathies, and synaptic dysfunction that provide potential therapeutic targets. This single-authored textbook utilizes ample figures and tables throughout in order to facilitate retention of the core concepts presented. Divided into 5 sections, the first section includes chapters focused on basic cellular processes. Section 2 includes chapters focused on cell communication while Section 3 focuses on the neuronal microenvironment. The fourth section focuses on the organization and interactions of circuits in the cortex, thalamus, and brainstem, underlying behavioral states such as sleep, sensory processing, and motor control. The fifth section addresses mechanisms of pain and neural control of survival. And the final section covers concepts on mechanisms of emotion, social behavior, memory, language, and executive functions with emphasis on dementia and behavioral disorders.
Preface
Molecular and Cellular Mechanisms
Overview: Cellular Components of the Nervous System and Disease Mechanisms
Organization of Cell Membranes
Intracellular Signaling
DNA: Epigenetic Control of Transcription and Repair Mechanisms
Messenger RNA Metabolism
Proteostasis
Vesicular Trafficking
Cytoskeleton
Axonal Transport
Axon and Myelin
Mitochondria and Energy Metabolism
Mechanisms of Cell Death and Axonal Degeneration
Growth Factors, Survival, and Regeneration
Excitability, Signal Communication, and Plasticity
Ion Channels and Channelopathies
Synaptic Transmission and Presynaptic Synaptopathies
Neurotransmission, Neuromodulation, and Plasticity
Glutamatergic Transmission and Synaptopathies
Inhibitory Amino Acid Neurotransmission and Synaptopathies
Cholinergic Transmission
Monoaminergic Systems
Microenvironment and Mechanisms of Injury and Repair
Astrocytes and Astrocyte–Neuron Interactions
Microglia and Neuroinflammation
Microenvironment in the Central Nervous System
Neuronal Interactions in Cortical and Subcortical Circuits
Neocortical Organization and Circuits
Hippocampal and Amygdala Circuits
Thalamus and Thalamocortical Interactions
Sleep–Wake Cycle and Circadian Rhythms
Behavioral State Control
Sensory Processing
Motor Cortex
Spinal Motor Control
Brainstem Mechanisms of Motor Control
Cerebellar Circuits
Basal Ganglia Circuits
Survival Systems
Peripheral and Spinal Mechanisms of Nociception
Central Processing and Modulation of Pain
Autonomic Control and Survival
Homeostasis and Adaptation
Cortical Networks and Cognitive Domains
Emotion and Social Cognition
Episodic Memory
Language
Executive Control
Index