Textbook in PDF format

Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses main aspects of synthesis, hydrolytic stability and solution equilibria of nucleosides, nucleotides and oligonucleotides, as well as synthesis of their structural analogs that are of interest in chemotherapy. In addition, recent achievements in chemistry of catalytic nucleic acids, development of oligonucleotide based drugs and novel strategies for their targeting and delivery are discussed. The central theme always is the correlation of structure and function.
Gives an overview of the chemistry and biology of nucleic acids in an easy-to-grasp manner.
Explains the connection between the structure of nucleic acids and their ability to form triple helical and quadruplex frameworks.
Nucleosides: structure, nomenclature and solution equilibria
Nucleosides: synthesis, transformation reactions and hydrolytic stability
Nucleotides
Nucleosides and nucleotides in chemotherapy
Oligonucleotides: synthesis
Oligonucleotides: reactions
Oligonucleotide conjugates
Nucleic acids: DNA
Nucleic acids: RNA
Catalytic nucleic acids
Nucleic acids as drugs and drug targets 1: oligodeoxyribonucleotides in chemotherapy
Nucleic acids as drugs and drug targets 2: RNA in chemotherapy
Nucleic acids as drugs and drug targets 3: target recognition and delivery