Vaccinology: Principles and Practice 
by W. John W. Morrow, Nadeem A. Sheikh, Clint S. Schmidt and D. Huw Davies
Wiley-Blackwell | September 2012 | ISBN-10: 1405185740 | PDF | 552 pages | 17.2 mb 
http://www.amazon.com/Vaccinology-Principles-Practice-John-Morrow/dp/1405185740

Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe.
-    Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application
-    Includes evaluation of vaccine efficacy and safety
-    Details clinical trial design, including regulatory requirements
-    Discusses the emerging field of active cellular immunotherapy
Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.

CONTENTS
Part 1 Introduction
1 Concept and Scope of Modern Vaccines, 3
Part 2 Principles of Vaccine Design
2 Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants, 15
3 Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules, 29
4 Understanding the Mucosal Immune System for Better Mucosal Vaccine Design, 47
5 Immunologic Memory: T Cells in Humans, 61
6 Immunologic Memory: B cells, 79
7 Utility of Mouse Models in Vaccine Design and Development, 94
8 Utility of Nonhuman Primate Models for Vaccines, 110
Part 3 Antigen Discovery
9 Sequence-Based Computational Approaches to Vaccine Discovery and Design, 133
10 Antigen Discovery for Vaccines Using High-throughput Proteomic Screening Technologies, 150
11 Phage Libraries, 168
Part 4 Antigen Engineering
12 Attenuated Bacterial Vaccines, 181
13 Virus-like Particles as Antigen Scaffolds, 196
14 Recombinant MVA vaccines: Optimization, Preclinical, and Product Development, 209
15 Recombinant Adenoviruses for Vaccination, 224
16 Recombinant Avipoxviruses, 237
17 Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy, 255
18 Nucleic Acid Vaccination, 275
19 Artificial Antigen-presenting Cells: Large Multivalent Immunogens, 286
Part 5 Delivery Systems
20 Transcutaneous Immunization via Vaccine Patch Delivery System, 303
21 Needle-free Jet Injection for Vaccine Administration, 324
22 Oral Vaccines: An Old Need and Some New Possibilities, 336
23 Adjuvants: From Serendipity to Rational Discovery, 348
24 Immunostimulatory Properties of Biodegradable Microparticles, 361
25 Co-administration of Co-stimulatory Moieties, 375
26 Toll Receptors in Relation to Adjuvant Effects, 393
Part 6 Regulatory Considerations
27 Regulatory Issues (FDA and EMA), 403
Part 7 Evaluating Vaccine Efficacy
28 Immune Monitoring Design within the Developmental Pipeline for an Immunotherapeutic or Preventive Vaccine, 419
29 Clinical Development Strategy: Nuts and Bolts, 441
30 Current Approaches to Identify and Evaluate Cancer Biomarkers for Patient Stratification, 452
Part 8 Implementing Immunizations/Therapies
31 Mass Immunization Strategies, 467
32 The Role of Mathematical Models in Vaccine Development and Public Health Decision Making, 480
33 Vaccine Safety, 509
Index, 525